Drug Information

Drug General Information
Drug ID
D00BZS
Former ID
DIB010607
Drug Name
Gimatecan
Synonyms
LBQ-707; ST-1480; ST-1481; Camptothecin analogs, Sigma-Tau; 7-cyano-camptothecin
Drug Type
Small molecular drug
Indication Breast cancer [ICD9: 174, 175; ICD10:C50] Phase 2 [532152]
Company
Sigma-Tau Ind Farm Riunite SpA
Formula
C25H25N3O5
Canonical SMILES
n12c(c3c(C2)c(c2c(n3)cccc2)/C=N/OC(C)(C)C)cc2c(c1=O)COC<br />(=O)[C@]2(O)CC
CAS Number
CAS 292618-32-7
PubChem Compound ID
9577124
Target and Pathway
Target(s) Toposisomerase-1 Target Info Inhibitor [532255]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 532152A phase II trial of oral gimatecan for recurrent glioblastoma. J Neurooncol. 2013 Feb;111(3):347-53.
Ref 532255Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect. Biochem Pharmacol. 2013 May 15;85(10):1433-40.

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