Drug Information

Drug General Information
Drug ID
D00BGN
Former ID
DNC008669
Drug Name
2-(1H-Imidazol-4-yl)benzene-1,3-diol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529619]
Formula
C9H8N2O2
Canonical SMILES
C1=CC(=C(C(=C1)O)C2=CN=CN2)O
InChI
1S/C9H8N2O2/c12-7-2-1-3-8(13)9(7)6-4-10-5-11-6/h1-5,12-13H,(H,10,11)
InChIKey
VMNQZTQDHXFNPD-UHFFFAOYSA-N
PubChem Compound ID
24971326
Target and Pathway
Target(s) Indoleamine 2,3-dioxygenase Target Info Inhibitor [529619]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation
L-kynurenine degradation
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
NAD de novo biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
African trypanosomiasis
NetPath Pathway TSLP Signaling Pathway
IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Tryptophan Metabolism
Reactome Tryptophan catabolism
WikiPathways Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 529619J Med Chem. 2008 Aug 28;51(16):4968-77. Epub 2008 Jul 30.Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.
Ref 529619J Med Chem. 2008 Aug 28;51(16):4968-77. Epub 2008 Jul 30.Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.

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