Drug Information

Drug General Information
Drug ID
D00ASH
Former ID
DNC000063
Drug Name
3-methoxydesaminokynurenine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535837]
Formula
C12H15NO4
Canonical SMILES
CC(CC(=O)C1=CC(=CC=C1)OC)(C(=O)O)N
InChI
1S/C12H15NO4/c1-12(13,11(15)16)7-10(14)8-4-3-5-9(6-8)17-2/h3-6H,7,13H2,1-2H3,(H,15,16)
InChIKey
WRBHWPHQKJOLHX-UHFFFAOYSA-N
PubChem Compound ID
56603744
PubChem Substance ID
134339603
Target and Pathway
Target(s) Kynureninase Target Info Inhibitor [535837]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation
L-kynurenine degradation
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
NAD de novo biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
NetPath Pathway TSLP Signaling Pathway
PathWhiz Pathway Tryptophan Metabolism
Reactome Tryptophan catabolism
WikiPathways Tryptophan metabolism
Metabolism of amino acids and derivatives
NAD Biosynthesis II (from tryptophan)
Selenium Micronutrient Network
References
Ref 535837Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase. BMC Biochem. 2003 Sep 24;4:13.
Ref 535837Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase. BMC Biochem. 2003 Sep 24;4:13.

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