Target Information

Target General Infomation
Target ID
T98179
Former ID
TTDR01018
Target Name
Phosphopantetheine adenylyltransferase
Gene Name
COASY
Synonyms
Dephospho-CoA pyrophosphorylase; PPAT; Pantetheine-phosphate adenylyltransferase; COASY
Target Type
Discontinued
Disease Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99]
Function
Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
BioChemical Class
Kinase
UniProt ID
Q13057 (180-358)
EC Number
EC 2.7.1.24
Sequence
VAGSPKQPVRGYYRGAVGGTFDRLHNAHKVLLSVACILAQEQLVVGVADKDLLKSKLLPE
LLQPYTERVEHLSEFLVDIKPSLTFDVIPLLDPYGPAGSDPSLEFLVVSEETYRGGMAIN
RFRLENDLEELALYQIQLLKDLRHTENEEDKVSSSSFRQRMLGNLLRPPYERPELPTCL
Drugs and Mode of Action
Drug(s) PTX-007011 Drug Info Terminated Bacterial infections [547646]
Inhibitor 2-Methyl-2,4-Pentanediol Drug Info [551393]
4'-Phosphopantetheine Drug Info [551393]
Adenosine-5'-Diphosphate Drug Info [551391]
Coenzyme A Drug Info [551393]
Dephospho Coenzyme A Drug Info [551391]
PTX-007011 Drug Info [551859]
Pathways
KEGG Pathway Pantothenate and CoA biosynthesis
Metabolic pathways
WikiPathways Metabolism of water-soluble vitamins and cofactors
References
Ref 547646Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018127)
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551859NME DIGEST. Drug News & Perspect 2002, 15(8):519, ISSN 0214-0934.

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