Target Information

Target General Infomation
Target ID
T94788
Former ID
TTDR01028
Target Name
Branched chain amino acid-dependent aminotransferase
Gene Name
BCAT2
Synonyms
BCAT; BCAT(c); BCAT(m); Branched-chain amino acid aminotransferase; ECA39 protein; PP18; Placental protein 18; BCAT2
Target Type
Research
Function
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.
BioChemical Class
Transferases of nitrogenous groups
Target Validation
T94788
UniProt ID
O15382
EC Number
EC2.6.1.42
Sequence
MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT
FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP
WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL
GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV
QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS
LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP
TMENGPELILRFQKELKEIQYGIRAHEWMFPV
Inhibitor Alpha-ketoisovalerate Drug Info [551393]
N'-(phenylsulfonyl)benzofuran-2-carbohydrazide Drug Info [527724]
N'-(phenylsulfonyl)quinoline-6-carbohydrazide Drug Info [527724]
N-[O-Phosphono-Pyridoxyl]-Isoleucine Drug Info [551393]
Pyridoxamine-5'-Phosphate Drug Info [551393]
Pathways
BioCyc Pathway Leucine degradation
Valine degradation
Isoleucine degradation
KEGG Pathway Valine, leucine and isoleucine degradation
Valine, leucine and isoleucine biosynthesis
Pantothenate and CoA biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
2-Oxocarboxylic acid metabolism
Biosynthesis of amino acids
PANTHER Pathway Alanine biosynthesis
Isoleucine biosynthesis
Leucine biosynthesis
Valine biosynthesis
WikiPathways Metabolism of amino acids and derivatives
References
Ref 527724Bioorg Med Chem Lett. 2006 May 1;16(9):2337-40. Epub 2005 Sep 6.The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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