Target Information

Target General Infomation
Target ID
T86918
Former ID
TTDS00397
Target Name
Pancreatic alpha-amylase
Gene Name
AMY2A
Synonyms
1,4-alpha-D-glucan glucanohydrolase; PA; AMY2A
Target Type
Clinical Trial
Disease Cystic fibrosis [ICD9: 277; ICD10: E84]
Pancreatic disease [ICD10: K85-K86]
BioChemical Class
Glycosylases
UniProt ID
P04746
EC Number
EC 3.2.1.1
Sequence
MKFFLLLFTIGFCWAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPP
NENVAIYNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGN
AVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLTGL
LDLALEKDYVRSKIAEYMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLNSNWFPAG
SKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWG
FVPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWP
RQFQNGNDVNDWVGPPNNNGVIKEVTINPDTTCGNDWVCEHRWRQIRNMVIFRNVVDGQP
FTNWYDNGSNQVAFGRGNRGFIVFNNDDWSFSLTLQTGLPAGTYCDVISGDKINGNCTGI
KIYVSDDGKAHFSISNSAEDPFIAIHAESKL
Drugs and Mode of Action
Drug(s) Pancrecarb Drug Info NDA filed Pancreatic disease [550604]
Liprotamase Drug Info Phase 3 Cystic fibrosis [522063]
Inhibitor 4,6-Dideoxy-4-Amino-Alpha-D-Glucose Drug Info [551393]
5-Hydroxymethyl-Chonduritol Drug Info [551393]
6-Deoxy-Alpha-D-Glucose Drug Info [551393]
Acarbose Derived Hexasaccharide Drug Info [551393]
Acarviostatin III03 Drug Info [536633]
Acarviostatin IV03 Drug Info [536633]
Alpha-acarviosinyl-(1-->7)-3-alpha-D-glucopyranosylpropen Drug Info [536748]
Alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen Drug Info [536748]
Beta-D-Glucose Drug Info [551393]
Hydroxycitric acid Drug Info [536413]
Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam Drug Info [551391]
Pyroglutamic Acid Drug Info [551393]
Modulator Liprotamase Drug Info [549848]
Pancrecarb Drug Info [550604]
References
Ref 522063ClinicalTrials.gov (NCT00500084) Phase III ALTU-135 CP Safety Trial. U.S. National Institutes of Health.
Ref 550604Clinical pipeline report, company report or official report of Digestive Care.
Ref 536413Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol. 2007 Jul;75(5):977-82. Epub 2007 May 3.
Ref 536633Four acarviosin-containing oligosaccharides identified from Streptomyces coelicoflavus ZG0656 are potent inhibitors of alpha-amylase. Carbohydr Res. 2008 Apr 7;343(5):882-92. Epub 2008 Jan 26.
Ref 536748Enzymatic synthesis of a selective inhibitor for alpha-glucosidases: alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen. J Agric Food Chem. 2008 Jul 9;56(13):5324-30. Epub 2008 Jun 14.
Ref 549848Clinical pipeline report, company report or official report of Anthera Pharmaceuticals.
Ref 550604Clinical pipeline report, company report or official report of Digestive Care.
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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