Target Information

Target General Infomation
Target ID
T86152
Former ID
TTDR00895
Target Name
NH(3)-dependentNAD(+) synthetase
Gene Name
efg
Synonyms
Diphosphopyridine nucleotide synthetase; NAD synthase; NAD synthetase; NAD(+)-synthetase; NAD+ synthase; NAD+ synthetase; NadE; Nicotinamide adenine dinucleotide synthetase; Nitrogen-regulatory protein; efg
Target Type
Research
Function
Catalyzes a keystep in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction.
BioChemical Class
Carbon-nitrogen ligase
UniProt ID
P18843
EC Number
EC 6.3.5.1
Sequence
MTLQQQIIKALGAKPQINAEEEIRRSVDFLKSYLQTYPFIKSLVLGISGGQDSTLAGKLC
QMAINELRLETGNESLQFIAVRLPYGVQADEQDCQDAIAFIQPDRVLTVNIKGAVLASEQ
ALREAGIELSDFVRGNEKARERMKAQYSIAGMTSGVVVGTDHAAEAITGFFTKYGDGGTD
INPLYRLNKRQGKQLLAALACPEHLYKKAPTADLEDDRPSLPDEVALGVTYDNIDDYLEG
KNVPQQVARTIENWYLKTEHKRRPPITVFDDFWKK
Inhibitor Alpha,Beta-Methyleneadenosine-5'-Triphosphate Drug Info [551393]
Deamido-Nad+ Drug Info [551393]
Diphosphate Drug Info [551393]
Nicotinamide-Adenine-Dinucleotide Drug Info [551393]
Pyrophosphate 2- Drug Info [551374]
References
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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