Target Information

Target General Infomation
Target ID
T69146
Former ID
TTDR00084
Target Name
Mitochondrial uncoupling protein 3
Gene Name
UCP3
Synonyms
Mitochondrial uncoupling protein 1; UCP 3; UCP3
Target Type
Clinical Trial
Disease Obesity [ICD9: 278; ICD10: E66]
Function
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
BioChemical Class
Mitochondrial carrier
UniProt ID
P55916
Sequence
MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG
VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI
LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK
GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV
VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRA
LMKVQMLRESPF
Drugs and Mode of Action
Drug(s) CL-316,243 Drug Info Phase 2 Obesity [533802], [540400]
Stimulator Beta 3-adrenoceptor Drug Info [534866]
Inducer CL-316,243 Drug Info [538030]
Pathways
WikiPathways Diurnally Regulated Genes with Circadian Orthologs
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Electron Transport Chain
References
Ref 533802Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats. Am J Physiol. 1994 Apr;266(4 Pt 2):R1371-82.
Ref 540400(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3462).
Ref 534866Development of beta 3-adrenoceptor agonists for the treatment of obesity and diabetes--an update. Diabetes Metab. 1999 Mar;25(1):11-21.
Ref 538030Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol. 1997 Apr;136(4):429-37.

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