Target Information

Target General Infomation
Target ID
T61997
Former ID
TTDR00362
Target Name
20S proteasome
Synonyms
MCP; Multicatalytic protease
Target Type
Successful
Disease Mantle cell lymphoma [ICD9: 200.4, 202.8, 203.0, 208.9; ICD10: C81-C86, C85.7, C90.0, C91-C95]
BioChemical Class
Peptidase
EC Number
EC 3.4.25.1
Drugs and Mode of Action
Drug(s) PS-341 Drug Info Approved Mantle cell lymphoma [546307], [551871]
Inhibitor PS-341 Drug Info [535318]
References
Ref 546307Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007364)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535318Selected novel anticancer treatments targeting cell signaling proteins. Oncologist. 2001;6(6):517-37.

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