Target Information

Target General Infomation
Target ID
T56143
Former ID
TTDI00075
Target Name
G protein-coupled receptor 35
Gene Name
GPR35
Synonyms
Gprotein coupled receptor 35; KYNA receptor; Kynurenic acid receptor; GPR35
Target Type
Research
Function
Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
BioChemical Class
GPCR rhodopsin
UniProt ID
Q9HC97
Sequence
MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMT
NLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRH
PLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGF
YLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVR
LAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKS
QDSLCVTLA
Agonist 2-oleoyl-LPA Drug Info [530825]
pamoic acid Drug Info [531193]
Pathways
WikiPathways GPCRs, Class A Rhodopsin-like
References
Ref 530825GPR35 is a novel lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2010 Apr 30;395(2):232-7.
Ref 531193Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of beta-arrestin-2 and activate Galpha13. Biochem J. 2010 Dec 15;432(3):451-9.

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