Target Information

Target General Infomation
Target ID
T49064
Former ID
TTDS00429
Target Name
Gastric triacylglycerol lipase
Gene Name
LIPF
Synonyms
GL; Gastric lipase; LIPF
Target Type
Clinical Trial
Disease Diabetes; Obesity [ICD9: 250, 278; ICD10: E08-E13, E66]
BioChemical Class
Carboxylic ester hydrolase
UniProt ID
P07098
EC Number
EC 3.1.1.3
Sequence
MWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILE
VNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRG
NTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFI
AFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQF
LATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKS
GKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPN
LIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK
Structure
1HLG
Drugs and Mode of Action
Drug(s) Cetilistat Drug Info Phase 3 Diabetes; Obesity [536271], [536710]
Inhibitor B-Octylglucoside Drug Info [551393]
Undecyl-Phosphinic Acid Butyl Ester Drug Info [551374]
Modulator Cetilistat Drug Info [536271]
Pathways
BioCyc Pathway Triacylglycerol degradation
KEGG Pathway Glycerolipid metabolism
Metabolic pathways
Fat digestion and absorption
NetPath Pathway EGFR1 Signaling Pathway
WikiPathways Triacylglyceride Synthesis
Fatty Acid Beta Oxidation
References
Ref 536271Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients. Int J Obes (Lond). 2007 Mar;31(3):494-9. Epub 2006 Sep 5.
Ref 536710Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50.
Ref 536271Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients. Int J Obes (Lond). 2007 Mar;31(3):494-9. Epub 2006 Sep 5.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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