Target Information

Target General Infomation
Target ID
T41666
Former ID
TTDR00219
Target Name
Hypoxanthine-guanine phosphoribosyltransferase
Gene Name
LACZ
Synonyms
GPRT; Guanine phosphoribosyltransferase; HGPRT; HGPRTase; HPRT; Hypoxanthine phosphoribosyltransferase; LACZ
Target Type
Research
Function
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
BioChemical Class
Pentosyltransferase
Target Validation
T41666
UniProt ID
P20035
EC Number
EC 2.4.2.8
Sequence
MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYD
IKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQ
STGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPL
WNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL
Structure
1CJB; 2VFA; 3OZF; 3OZG; 1BZY; 1D6N; 1HMP; 1Z7G; 2VFA; 3GEP; 3GGC; 3GGJ; 4IJQ; 4KN6; 4RAB; 4RAC; 4RAD; 4RAN; 4RAO; 4RAQ
Inhibitor 3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol Drug Info [551393]
5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine Drug Info [551393]
7-Hydroxy-Pyrazolo[4,3-D]Pyrimidine Drug Info [551391]
9-Deazaguanine Drug Info [551393]
9-[2-(1-Phosphonobutan-2-yloxy)ethyl]guanine Drug Info [530305]
9-[2-(1-Phosphonobutan-2-yloxy)ethyl]hypoxanthine Drug Info [530305]
9-[2-(1-Phosphonopropan-2-yloxy)ethyl]guanine Drug Info [530305]
Acetate Ion Drug Info [551393]
Alpha-Phosphoribosylpyrophosphoric Acid Drug Info [551374]
Carboxylic PRPP Drug Info [551393]
Formic Acid Drug Info [551393]
Formycin B Drug Info [551393]
Guanosine-5',3'-Tetraphosphate Drug Info [551393]
Guanosine-5'-Monophosphate Drug Info [551393]
Inosinic Acid Drug Info [551393]
Pyrophosphate 2- Drug Info [551374]
Pathways
KEGG Pathway Purine metabolism
Drug metabolism - other enzymes
Metabolic pathways
PathWhiz Pathway Purine Metabolism
Reactome Purine salvage
WikiPathways Nucleotide Metabolism
Mesodermal Commitment Pathway
Endoderm Differentiation
Metabolism of nucleotides
References
Ref 530305Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. Epub 2009 Jul 25.Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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