Target Information

Target General Infomation
Target ID
T16761
Target Name
Pneumocystis carinii dihydropteroate synthase
Gene Name
fol1
Synonyms
fol1
Target Type
Successful
Disease Pneumocystis carinii pneumonia [ICD9: 136.3; ICD10: B20.6]
UniProt ID
P29251 (463-740)
Sequence
SFRSYKAPTYIMAILNLTPDSFFDGGIHSYDSVLIDVEKFINAGATIIDIGGQSTRPGSY
IIPLEEEIFRVIPAIKYLQKTYPDILISIDTFRSEVAEQAVKAGASLVNDISGGRYDPKM
FNTVARLKVPICIMHMRGNFLNMDNLTDYGTDIIEQITIELEKLLNSAEKSGIPRWNIIL
DPGLGFSKTLHQNIELLRRFNELKSKNCFNGLPWLLGPSRKRFTGFITGDNMPKDRIWGT
VAAVVASISGGCDIIRVHDVYEMYKISKMSDAIWKEIY
Drugs and Mode of Action
Drug(s) Dapsone Drug Info Approved Pneumocystis carinii pneumonia [536602]
Modulator Dapsone Drug Info [556264]
References
Ref 536602The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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