Target Information

Target General Infomation
Target ID
T08813
Former ID
TTDR00977
Target Name
CAMP-dependent protein kinase type I-alpha regulatory chain
Gene Name
PRKAR1A
Synonyms
CAMP-dependent protein kinase (PKA); PKA RIalpha-subunit; RIalpha subunit of cAMP-dependent protein kinase; TSE1; Tissue-specific extinguisher-1; PRKAR1A
Target Type
Research
Function
Regulatorysubunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
BioChemical Class
Kinase
Target Validation
T08813
UniProt ID
P10644
EC Number
EC 2.7.1.37
Sequence
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA
AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG
PCSDILKRNIQQYNSFVSLSV
Inhibitor 5-(2-methylpiperazin-1-ylsulfonyl)isoquinoline Drug Info [534220]
AdcAhxArg4Lys(biotin)-PEG-OMe Drug Info [526704]
AdcAhxArg4Lys-PEGOMe Drug Info [526704]
AdcAhxArg4NH(CH2)6NH2 Drug Info [526704]
AdcAhxArg6 Drug Info [526704]
AdoC(Ahx)Arg6 Drug Info [525511]
AdoC(Aoc)Arg6 Drug Info [525511]
AdoC(Aun)Arg6 Drug Info [525511]
AdoC(beta-Ala)2AlaArg6 Drug Info [525511]
AdoC(beta-Ala)Arg6 Drug Info [525511]
AdoC(betaAsp)2AlaArg6 Drug Info [525511]
AdoC(Dpr)2AlaArg6 Drug Info [525511]
AdoC(GABA)Arg6 Drug Info [525511]
AdoCGlyArg6 Drug Info [525511]
Cyclic Adenosine Monophosphate Drug Info [551393]
Cyclic Guanosine Monophosphate Drug Info [551393]
RO-316233 Drug Info [528701]
Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate Drug Info [551393]
Pathways
KEGG Pathway Apoptosis
Insulin signaling pathway
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Endothelin signaling pathway
Hedgehog signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group II pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Transcription regulation by bZIP transcription factor
GABA-B receptor II signaling
Pathway Interaction Database Alpha4 beta1 integrin signaling events
PathWhiz Pathway Muscle/Heart Contraction
Reactome PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog &#039
off&#039
state
Factors involved in megakaryocyte development and platelet production
WikiPathways SIDS Susceptibility Pathways
Calcium Regulation in the Cardiac Cell
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Mesodermal Commitment Pathway
DAG and IP3 signaling
Regulation of Water Balance by Renal Aquaporins
miRs in Muscle Cell Differentiation
Opioid Signalling
Integration of energy metabolism
Factors involved in megakaryocyte development and platelet production
References
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 526704Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase.
Ref 528701J Med Chem. 1992 Jan;35(1):177-84.Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.
Ref 534220J Biol Chem. 1996 Oct 18;271(42):26157-64.Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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