Target Information

Target General Infomation
Target ID
T00335
Former ID
TTDR00949
Target Name
Elongation factor 1-alpha
Gene Name
EEF1A
Synonyms
EF-1 alpha; EF-1-alpha-1; EF-Tu; Elongation factor Tu; EEF1A
Target Type
Clinical Trial
Disease Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99]
Function
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
BioChemical Class
GTP-binding elongation factor family
UniProt ID
Q90835
Sequence
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL
DKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGV
GEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKK
IGYNPDTVAFVPISGWNGDNMLEPSSNMPWFKGWKVTRKDGNASGTTLLEALDCILPPTR
PTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALS
EALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPV
LDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMIPGKPMCVESFSDYPP
LGRFAVRDMRQTVAVGVIKAVDKKAGGAGKVTKSAQKAQKAK
Drugs and Mode of Action
Drug(s) Ge2270a Drug Info Phase 1 Bacterial infections [544022]
Inhibitor Ge2270a Drug Info [551393]
Guanosine-5'-Diphosphate Drug Info [551393]
References
Ref 544022In vitro antimicrobial activity of a new antibiotic, MDL 62,879 (GE2270 A).. Antimicrob Agents Chemother. 1993 April; 37(4): 741-745.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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