Target General Information
Target ID	T93344
Target Name	Squalene monooxygenase
Synonyms	ERG1; Oxidosqaulene cyclase; SE; Squalene epoxidase; SQLE
Target Type	Successful
Gene Name	SQLE
Biochemical Class	Oxidoreductases acting on paired donors
UniProt ID	ERG1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Coronary artery disease
Example drug	SDZ-87-469			Terminated	[551702], [1572592]
Tissue	Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.19 Z-score: 1.16 P-value: 5.26E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Familial hypercholesterolemia
Example drug	FR-194738			Terminated	[546677], [1572592]
Tissue	Whole blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.45 Z-score: 2.51 P-value: 7.14E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Atopic dermatitis
Tissue	Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.65 Z-score: -2.30 P-value: 2.61E-04
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref
Ref 546677	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009590)
Ref 551702	Chemotherapy of fungal diseases. 1990. Page(525-550).
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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