Target General Information
Target ID	T40694
Target Name	PLK1 serine/threonine kinase
Synonyms	Mitoticserine-threonine kinase polo-like kinase 1; PLK-1; Plk1; Polo-like kinase 1; STPK13; Serine-threonine protein kinase 13; PLK1
Target Type	Clinical Trial
Gene Name	PLK1
Biochemical Class	Kinase
UniProt ID	PLK1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Acute myelocytic leukemia
Example drug	Volasertib			Phase 2	[524843], [542862], [1572592]
Tissue	Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.38 Z-score: -0.72 P-value: 4.16E-07
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 542862	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7947).
Ref 524843	ClinicalTrials.gov (NCT02198482) Trial of Intensive Chemotherapy With or Without Volasertib in Patients With Newly Diagnosed Acute Myeloid Leukemia. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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