Drug Information

Drug General Information
Drug ID
D0R5AA
Drug Name
Xmab5871
Drug Type
Monoclonal antibody
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Phase 1/2 [889425]
Company
Xencor
Target and Pathway
Target(s) CD32b Target Info Modulator [889442]
B-lymphocyte antigen CD19 Target Info Modulator [889442]
KEGG Pathway Phagosome
Osteoclast differentiation
B cell receptor signaling pathway
Fc gamma R-mediated phagocytosis
Staphylococcus aureus infection
Tuberculosis
Measleshsa04151:PI3K-Akt signaling pathway
Hematopoietic cell lineage
Epstein-Barr virus infection
Primary immunodeficiency
NetPath Pathway Leptin Signaling PathwayNetPath_19:IL-7 Signaling Pathway
PANTHER Pathway B cell activation
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
BCR signaling pathwaybcr_5pathway:BCR signaling pathway
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellR-HSA-1257604:PIP3 activates AKT signaling
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Constitutive Signaling by Aberrant PI3K in Cancer
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
WikiPathways Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellWP2806:Human Complement System
Signaling by the B Cell Receptor (BCR)
PIP3 activates AKT signaling
B Cell Receptor Signaling Pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
References
Ref 889425ClinicalTrials.gov (NCT02867098) XmAb5871 Bioavailability Study
Ref 889442Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. doi: 10.1038/nrd4478.

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