Drug Information

Drug General Information
Drug ID
D0B6DV
Former ID
DIB013918
Drug Name
CT-10
Synonyms
CT-10; GGTase inhibitors (cancer); GGTase inhibitors (cancer), Cellona Therapeutics/Duke University; Geranylgeranyl transferase inhibitors (cancer), Cellona Therapeutics/Duke University
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543909]
Company
Duke University
Target and Pathway
Target(s) Geranyltranstransferase Target Info Inhibitor [543909]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Trans, trans-farnesyl diphosphate biosynthesis
Geranylgeranyldiphosphate biosynthesis
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
References
Ref 543909(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 643).
Ref 543909(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 643).

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