Drug Information

Drug General Information
Drug ID
D03OMK
Former ID
DIB001757
Drug Name
DM-107
Synonyms
MDPK-67; MDPK-67b; Kallikrein 2 inhibitor (anticancer), Med Discovery; Kallikrein 2 inhibitor (dermatological disorders), Dermadis
Indication Atopic dermatitis [ICD9: 691.8, 692.9; ICD10:L00-L99] Investigative [543612]
Company
Med Discovery SA
Target and Pathway
Target(s) Tissue kallikrein Target Info Inhibitor [543612]
KEGG Pathway Endocrine and other factor-regulated calcium reabsorption
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Reactome Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways Prostate Cancer
References
Ref 543612(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2372).
Ref 543612(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2372).

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