Drug Information

Drug General Information
Drug ID
D0C1OJ
Former ID
DIB011831
Drug Name
Debio-0930
Synonyms
MT-63-78; AMPK stimulator (oral, cancer), Mercury Therapeutics/Debiopharm SA; Adenosine monophosphate activated protein kinase stimulator (oral, cancer), Mercury Therapeutics/Debiopharm SA
Indication Metabolic disorders [ICD9: 270-279; ICD10:E70-E89] Investigative [543438]
Company
Mercury Therapeutics Inc
Target and Pathway
Target(s) AMP-activated protein kinase Target Info Stimulator [543438]
KEGG Pathway FoxO signaling pathway
Regulation of autophagy
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Circadian rhythm
Insulin signaling pathway
Adipocytokine signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hypertrophic cardiomyopathy (HCM)
Reactome Translocation of GLUT4 to the plasma membrane
Macroautophagy
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
TP53 Regulates Metabolic Genes
WikiPathways Insulin Signaling
Energy dependent regulation of mTOR by LKB1-AMPK
JAK/STAT
BDNF signaling pathway
Leptin signaling pathway
SREBF and miR33 in cholesterol and lipid homeostasis
SREBP signalling
Signaling by Insulin receptor
TOR Signaling
AMPK Signaling
References
Ref 543438(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1540).
Ref 543438(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1540).

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