Drug Information

Drug General Information
Drug ID
D03TYJ
Former ID
DIB008589
Drug Name
ATHX-105
Synonyms
ATH-88651; 5-HT2c receptor agonists (obesity), Athersys Inc
Indication Obesity [ICD9: 278; ICD10:E66] Phase 2 [522405]
Company
Athersys
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Agonist [544074]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 522405ClinicalTrials.gov (NCT00735683) A Short-Term Study to Examine the Effects of ATHX-105 Phosphate on Weight Loss and Safety. U.S. National Institutes of Health.
Ref 544074Pharmacological targeting of the serotonergic system for the treatment of obesity. J Physiol. 2009 January 1; 587(Pt 1): 49-60.

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