Drug Information

Drug General Information
Drug ID
D04MZR
Former ID
DIB002471
Drug Name
Bucelipase alfa
Synonyms
Exinalda; Kiobrina; BSSL, Biovitrum; Bile salt stimulated lipase, Arexis; Bile salt stimulated lipase, Biovitrum; Bile salt stimulated lipase, PPL Therapeutics; HrBSSL, Biovitrum; Human recombinant bile salt stimulated lipase, Biovitrum; TgBSSL, PPL Therapeutics
Indication Exocrine pancreatic insufficiency [ICD10:K86.8] Phase 3 [523584]
Company
Astra Hassle AB
Target and Pathway
Target(s) Bile-salt-activated lipase Target Info Modulator [522422]
BioCyc Pathway Triacylglycerol degradation
WikiPathways Lipid digestion, mobilization, and transport
References
Ref 523584ClinicalTrials.gov (NCT01413581) Comparison of rhBSSL With Placebo When Added to Infant Formula or Pasteurized Breast Milk During 4 Weeks of Treatment in Preterm Infants. U.S. National Institutes of Health.
Ref 522422ClinicalTrials.gov (NCT00743483) Efficacy of Bucelipase Alfa (BSSL) in Patients With Cystic Fibrosis and Pancreatic Insufficiency. U.S. National Institutes of Health.

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