Drug Information

Drug General Information
Drug ID
D0Y1VT
Former ID
DIB013029
Drug Name
VEGF-2 gene therapy
Synonyms
PhVEGF165; VEGF-2 gene therapy (diabetic neuropathy/ critical limb ischemia); VEGF-2 gene therapy (diabetic neuropathy/ critical limb ischemia), Northwestern University
Indication Diabetic neuropathy [ICD9: 250, 250.6, 356.0, 356.8; ICD10:E11.40] Phase 1 [534594]
Company
St Elizabeths Medical Center of Boston Inc
Target and Pathway
Target(s) VEGF receptor Target Info Modulator [534161]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritis
References
Ref 534594Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation. 1998 Mar 31;97(12):1114-23.
Ref 534161Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet. 1996 Aug 10;348(9024):370-4.

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