Drug Information

Drug General Information
Drug ID
D0T7LV
Former ID
DIB003764
Drug Name
LIPO-4
Synonyms
HIV vaccine (four peptide), INRS
Drug Type
Vaccine
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 1 [521652]
Company
INRS-Institut Armand-Frappier
Target and Pathway
Target(s) T-cell surface glycoprotein CD4 Target Info [532427]
T-cell surface glycoprotein CD8 Target Info [532427]
KEGG Pathway Cell adhesion molecules (CAMs)
Antigen processing and presentation
Hematopoietic cell lineage
T cell receptor signaling pathway
Primary immunodeficiencyhsa04514:Cell adhesion molecules (CAMs)
Primary immunodeficiency
NetPath Pathway Leptin Signaling Pathway
Pathway Interaction Database TCR signaling in na&#xef
IL12-mediated signaling events
CXCR4-mediated signaling events
C-MYB transcription factor network
IL23-mediated signaling events
Arf1 pathway
Notch-mediated HES/HEY network
IL12 signaling mediated by STAT4
Reactome Binding and entry of HIV virion
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
WikiPathways TCR Signaling Pathway
Cytokines and Inflammatory Response
Host Interactions of HIV factors
Defensins
HIV Life Cycle
TCR signaling
Costimulation by the CD28 family
References
Ref 521652ClinicalTrials.gov (NCT00121121) Safety of Intradermal Versus Intramuscular Administration of HIV Lipopeptides in HIV Uninfected Adult Volunteers. U.S. National Institutes of Health.
Ref 532427Long-term CD4(+) and CD8(+) T-cell responses induced in HIV-uninfected volunteers following intradermal or intramuscular administration of an HIV-lipopeptide vaccine (ANRS VAC16). Vaccine. 2013 Sep 13;31(40):4406-15.

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