Drug Information

Drug General Information
Drug ID
D08UHV
Former ID
DNCL002365
Drug Name
AMG 780
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1 [549765]
Target and Pathway
Target(s) Angiopoietin-1 Target Info Modulator [549766]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
PI3K-Akt signaling pathway
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TNFalpha Signaling Pathway
FSH Signaling Pathway
PANTHER Pathway Angiogenesis
Pathway Interaction Database Angiopoietin receptor Tie2-mediated signaling
SHP2 signaling
Reactome Tie2 Signaling
RAF/MAP kinase cascade
WikiPathways Cell surface interactions at the vascular wall
Angiogenesis
References
Ref 549765Development and preclinical testing of AMG 780, a fully human antibody targeting angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2). Cancer Research. 10/2014; 74(19 Supplement):1022-1022.
Ref 549766Development and preclinical testing of AMG 780, a fully human antibody targeting angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2). Cancer Research. 10/2014; 74(19 Supplement):1022-1022.

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