TTD | Drug: D0AK5G

Drug General Information
Drug ID	D0AK5G
Former ID	DIB003241
Drug Name	RPAF-AH
Indication	Sepsis [ICD9: 995.91; ICD10:A40, A41]		Discontinued in Phase 3	[521515]
Company	ICOS Corp
CAS Number	CAS 76901-00-3
Target and Pathway
Target(s)	Lipoprotein-associated phospholipase A2	Target Info	Modulator	[546181]
KEGG Pathway	Ether lipid metabolism
	Metabolic pathways
	Biosynthesis of antibiotics
Pathway Interaction Database	Lissencephaly gene (LIS1) in neuronal migration and development
WikiPathways	IL1 and megakaryotyces in obesity
WikiPathways	Synthesis, Secretion, and Deacylation of Ghrelin
References
Ref 521515	ClinicalTrials.gov (NCT00037687) Safety and Efficacy of Recombinant Human Platelet-Activating Factor Acetylhydrolase for the Treatment of Severe Sepsis. U.S. National Institutes of Health.
Ref 546181	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006777)

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Drug Information