Drug Information

Drug General Information
Drug ID
D01KKB
Former ID
DIB015223
Drug Name
PW-2101
Synonyms
Antihypertensive (oral once-daily, TIMERx), Penwest
Indication Angina pectoris [ICD9: 413; ICD10:I20] Discontinued in Preregistration [547795]
Company
Penwest Pharmaceuticals
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Antagonist [549748]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 547795Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019361)
Ref 549748PW 2101 Penwest discontinued, USA (hypertension) Penwest non-approvable, USA (hypertension), R & D Focus Drug News. July 11, 2005

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