Drug Information

Drug General Information
Drug ID
D03GNR
Former ID
DIB015457
Drug Name
ANA-975
Synonyms
Isatoribine prodrug, Anadys; ANA-245 prodrug, Anadys; ANA-97X program, Anadys
Indication Immuno-modulator [ICD9: 135, 691.8, 692.9, 710-719, 714; ICD10:D86, L20, L20-L30, M00-M25, M05-M06] Discontinued in Phase 1 [547967]
Company
Anadys Pharmaceuticals Inc
Target and Pathway
Target(s) Toll-like receptor 7 Target Info Agonist [536564]
KEGG Pathway Toll-like receptor signaling pathway
Measles
Influenza A
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Reactome Trafficking and processing of endosomal TLR
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88 dependent cascade initiated on endosome
Trafficking and processing of endosomal TLR
Regulation of toll-like receptor signaling pathway
References
Ref 547967Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020825)
Ref 536564Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine. Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):635-40.

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