Drug Information

Drug General Information
Drug ID
D00XPA
Former ID
DCL000857
Drug Name
L-759274
Indication Severe mood disorders; Depression [ICD9: 296, 311; ICD10:F30-F39, F32] Discontinued in Phase 3 [536580]
Company
Merck
CAS Number
CAS 737803-81-5
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [536580]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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