Drug Information

Drug General Information
Drug ID
D07SCP
Former ID
DIB016609
Drug Name
MMP-12 inhibitors
Synonyms
MMP-12 inhibitors (inflammatory diseases); MMP-12 inhibitors (inflammatory diseases), Bracco; Matrix metalloproteinase-12 inhibitors (inflammatory diseases), Bracco
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Investigative [552154]
Company
Bracco SpA
Canonical SMILES
c1(ccc(cc1)OC)Oc1ccc(S(=O)(=O)c2c(CC(=O)NO)cccc2)cc1
Target and Pathway
Target(s) MMP-12 Target Info Inhibitor [543453]
NetPath Pathway IL1 Signaling Pathway
IL5 Signaling Pathway
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
WikiPathways TGF beta Signaling Pathway
Degradation of collagen
Matrix Metalloproteinases
References
Ref 552154WO patent application no. 1999042443A1, Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases.
Ref 543453(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1636).

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