Drug Information

Drug General Information
Drug ID
D03QXD
Former ID
DIB004981
Drug Name
RXP-470
Synonyms
RXP-470; MMP-12 inhibitors (atherosclerosis); MMP-12 inhibitors (atherosclerosis), CEA; RXP-470 derivatives (atherosclerosis), CEA
Indication Atherosclerosis [ICD9: 414.0, 440; ICD10:I70] Investigative [543453]
Company
Commissariat a l`Energie Atomique
Canonical SMILES
c1(c2cc(on2)C[C@H](CP(=O)(O)c2ccc(cc2)Br)C(=O)N[C@H](C(<br />=O)N[C@H](C(=O)N)CCC(=O)O)CCC(=O)O)ccc(cc1)c1cccc(c1)Cl
Target and Pathway
Target(s) MMP-12 Target Info Inhibitor [543453]
NetPath Pathway IL1 Signaling Pathway
IL5 Signaling Pathway
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
WikiPathways TGF beta Signaling Pathway
Degradation of collagen
Matrix Metalloproteinases
References
Ref 543453(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1636).
Ref 543453(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1636).

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