Drug Information

Drug General Information
Drug ID
D0PP5M
Former ID
DIB009730
Drug Name
BPH-652
Synonyms
FX24B-04652; Dehydrosqualene synthase inhibitor (MRSA), AuricX
Drug Type
Small molecular drug
Indication Hypercholesterolemia [ICD10:E78] Investigative [543910]
Company
AuricX Pharmaceuticals Inc
Formula
C16H16K3O7PS
Canonical SMILES
[K+].[K+].[K+].S(=O)(=O)([O-])C(P(=O)([O-])[O-])CCCc1cc<br />cc(c1)Oc1ccccc1
PubChem Compound ID
25244957
Target and Pathway
Target(s) Squalene synthetase Target Info Inhibitor [543910]
BioCyc Pathway Cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
Cholesterol biosynthesis III (via desmosterol)
Cholesterol biosynthesis I
Superpathway of cholesterol biosynthesis
Epoxysqualene biosynthesis
KEGG Pathway Steroid biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
WikiPathways Statin Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
Cholesterol biosynthesis
References
Ref 543910(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 645).
Ref 543910(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 645).

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