Drug Information

Drug General Information
Drug ID
D03ZDC
Former ID
DNC001003
Drug Name
NE21650
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540151]
Formula
C8H13NO7P2
InChI
InChI=1S/C8H13NO7P2/c9-7-4-2-1-3-6(7)5-8(10,17(11,12)13)18(14,15)16/h1-4,10H,5,9H2,(H2,11,12,13)(H2,14,15,16)
InChIKey
VJXYJONFUZXZJZ-UHFFFAOYSA-N
CAS Number
CAS 169758-66-1
PubChem Compound ID
9994754
PubChem Substance ID
14973931, 24253749, 26683781, 44046075, 57373974, 78568102, 103470386, 104059656, 135650699, 247803854
Target and Pathway
Target(s) Farnesyl pyrophosphatesynthetase Target Info Inhibitor [535340]
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 540151(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3167).
Ref 535340Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase. Biochem Biophys Res Commun. 2002 Jan 18;290(2):869-73.

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