Drug Information

Drug General Information
Drug ID
D0N1RG
Former ID
DIB014091
Drug Name
SoRI-9409
Drug Type
Small molecular drug
Indication Alcohol use disorders [ICD9: 303; ICD10:F10.2] Preclinical [548793]
Company
Southern Research Institute
Formula
C29H27ClN2O3
Canonical SMILES
[C@]123[C@@]4([C@H](N(CC5CC5)CC3)Cc3c1c(O[C@H]2c1c(C4)c<br />c(cn1)c1ccc(cc1)Cl)c(cc3)O)O
CAS Number
CAS 248273-61-2
PubChem Compound ID
9805452
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Antagonist [526028]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 548793Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028893)
Ref 526028In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence. J Pharmacol Exp Ther. 2001 May;297(2):597-605.

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