Drug Information

Drug General Information
Drug ID
D0PU5L
Former ID
DIB012793
Drug Name
Adaprolol maleate-SME
Synonyms
Adaprolol; Adaprolol maleate; CDDD-2803; HGP-2; Submicron Emulsion, Pharmos; Adaprolol maleate-SME, Pharmos
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Discontinued in Phase 2 [545496]
Company
Pharmos Corp
Canonical SMILES
C12(CC3CC(C1)CC(C2)C3)CCOC(=O)Cc1ccc(OCC(CNC(C)C)O)cc1.<br />C(=O)(/C=C\C(=O)O)O
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Modulator [534192]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 545496Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003472)
Ref 534192Synthesis and pharmacological activity of adaprolol enantiomers: a new soft drug for treating glaucoma. J Ocul Pharmacol Ther. 1996 Summer;12(2):115-22.

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