Drug Information

Drug General Information
Drug ID
D0O0PY
Former ID
DIB010195
Drug Name
Pagoclone
Synonyms
IP-456; RP-59037; RP-62955
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Phase 2/3 [522559]
Company
Rhone-Poulenc SA
Formula
C23H22ClN3O2
Canonical SMILES
N1(C(=O)c2c(C1CC(=O)CCC(C)C)cccc2)c1nc2nc(ccc2cc1)Cl
CAS Number
CAS 133737-32-3
PubChem Compound ID
131664
Target and Pathway
Target(s) GABA A receptor Target Info Modulator [528204]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 522559ClinicalTrials.gov (NCT00830154) A Study to Assess the Efficacy and Safety of Pagoclone for Adults With Stuttering. U.S. National Institutes of Health.
Ref 528204Evaluation of the abuse potential of pagoclone, a partial GABAA agonist. J Clin Psychopharmacol. 2006 Jun;26(3):268-73.

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