Drug Information

Drug General Information
Drug ID
D09LMK
Former ID
DIB001549
Drug Name
Lu-AA21004
Drug Type
Small molecular drug
Indication Mood disorder [ICD10:F30-F39] Phase 3 [532217]
Company
Lundbeck; takeda pharmaceuticals
Formula
C18H22N2S
Canonical SMILES
c1(ccc(c(c1)C)Sc1ccccc1N1CCNCC1)C.Cl
PubChem Compound ID
9966051
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Modulator [531563], [532217], [532651]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 532217Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats. Pharmacol Biochem Behav. 2013 Apr;105:41-50.
Ref 531563A double-blind, randomized, placebo-controlled, active reference study of Lu AA21004 in patients with major depressive disorder. Int J Neuropsychopharmacol. 2012 Jun;15(5):589-600.
Ref 532217Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats. Pharmacol Biochem Behav. 2013 Apr;105:41-50.
Ref 5326512013 FDA drug approvals. Nat Rev Drug Discov. 2014 Feb;13(2):85-9.

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