Drug Information

Drug General Information
Drug ID
D0C3SW
Former ID
DNCL001692
Drug Name
Lesinurad
Drug Type
Small molecular drug
Indication Hyperuricaemia [ICD9: 274, 274.00274.1274.8274.9, 790.6; ICD10:E79.0, M10] Approved [523730], [542652]
Company
Ardea Biosciences
Formula
C17H14BrN3O2S
InChI
InChI=1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)
InChIKey
FGQFOYHRJSUHMR-UHFFFAOYSA-N
PubChem Compound ID
53465279
PubChem Substance ID
135267370, 135626658, 141682643, 160698094, 163620844, 163686172, 186022493, 198964591, 223366008, 224297829, 227115271, 243322229, 251963128, 252216185, 252440600, 252479355
Target and Pathway
Target(s) Solute carrier family 22 member 12 Target Info Modulator [543360]
WikiPathways Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 523730ClinicalTrials.gov (NCT01493531) Combining Lesinurad With Allopurinol in Inadequate Responders. U.S. National Institutes of Health.
Ref 542652(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7673).
Ref 543360(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1031).

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