Drug Information

Drug General Information
Drug ID
D0D5FQ
Former ID
DCL000417
Drug Name
Agatolimod
Indication Lung cancer [ICD9: 162; ICD10:C33-C34] Discontinued in Phase 2 [547005]
Company
Pfizer
Target and Pathway
Target(s) Toll-like receptor 9 Target Info Agonist [536475], [549974]
KEGG Pathway Toll-like receptor signaling pathway
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Tuberculosis
Measles
Herpes simplex infection
NetPath Pathway BCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Reactome PI3K Cascade
Trafficking and processing of endosomal TLR
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88 dependent cascade initiated on endosome
Trafficking and processing of endosomal TLR
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Regulation of toll-like receptor signaling pathway
References
Ref 547005Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011959)
Ref 536475CPG-7909 (PF-3512676, ProMune): toll-like receptor-9 agonist in cancer therapy. Expert Opin Biol Ther. 2007 Aug;7(8):1257-66.
Ref 549974Pfizer. Product Development Pipeline. March 31 2009.

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