Drug Information

Drug General Information
Drug ID
D0T0PN
Former ID
DNC000470
Drug Name
CP-122721
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Phase 2 [546318]
Formula
C20H23F3N2O2
Canonical SMILES
COC1=C(C=C(C=C1)OC(F)(F)F)CNC2CCCNC2C3=CC=CC=C3
InChI
1S/C20H23F3N2O2/c1-26-18-10-9-16(27-20(21,22)23)12-15(18)13-25-17-8-5-11-24-19(17)14-6-3-2-4-7-14/h2-4,6-7,9-10,12,17,19,24-25H,5,8,11,13H2,1H3/t17-,19-/m0/s1
InChIKey
ZIWFCOIGUNPHPM-HKUYNNGSSA-N
CAS Number
CAS 145742-28-5
PubChem Compound ID
9821217
PubChem Substance ID
14780102, 14902445, 24124685, 44857177, 78634444, 103309381, 103962360, 124954232, 129909114, 137034189, 140143344, 144210525, 198985924, 226520674, 241036480
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [536307]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 546318Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007429)
Ref 536307A review of drug options in age-related macular degeneration therapy and potential new agents. Expert Opin Pharmacother. 2006 Dec;7(17):2355-68.

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