Drug Information

Drug General Information
Drug ID
D0K4MU
Former ID
DIB006039
Drug Name
CROBENETINE HYDROCHLORIDE
Synonyms
CROBENETINE; CROBENETINE); BIII-890-CL; Crobenetine < Prop INN >; Crobenetine hydrochloride < Prop INNM >; (2R,6S)-3-[2(S)-Benzyloxypropyl]-6,11,11-trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ol; (2R,6S)-3-[2(S)-Benzyloxypropyl]-6,11,11-trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ol hydrochloride
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Phase 2 [524933]
Canonical SMILES
C[C@@H](CN1CC[C@H]2c3ccccc3C[C@@H]1C2(C)C)OCc4ccccc4
InChI
1S/C24H31NO/c1-18(26-17-19-9-5-4-6-10-19)16-25-14-13-22-21-12-8-7-11-20(21)15-23(25)24(22,2)3/h4-12,18,22-23H,13-17H2,1-3H3/t18-,22-,23+/m0/s1
InChIKey
ILVITZMPXQQPBD-OFAXGOBFSA-N
CAS Number
CAS 221019-25-6
Target and Pathway
Target(s) Sodium channel Target Info Antagonist [526220], [551871]
KEGG Pathway Dopaminergic synapse
Reactome Interaction between L1 and Ankyrins
References
Ref 524933ClinicalTrials.gov (NCT02251197) Safety and Tolerability of BIII 890 in Patients With Acute Ischemic Stroke. U.S. National Institutes of Health.
Ref 526220Analgesic activity of a novel use-dependent sodium channel blocker, crobenetine, in mono-arthritic rats. Br J Pharmacol. 2001 Dec;134(8):1742-8.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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