Drug Information

Drug General Information
Drug ID
D02SKA
Former ID
DIB014627
Drug Name
FCE-22716
Synonyms
1-(6-Methylergolin-8beta-yl)hydantoin; 1-[[(8beta)-6-Methylergolin-8-yl]methyl]-2,4-imidazolidinedione; 7beta-(2,4,-Dioxo-1-imidazolidinylmethyl)-9-methyl-2,5balpha,6,7,8,9,9abeta,10-octahydroindolo[4,3a,3-f,g]quinoline; 8beta-(2,4-Dioxo-1-imidazolidinylmethyl)-6-methylergoline
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 2 [533340]
Formula
C19H22N4O2
Canonical SMILES
CN1CC(CC2C1CC3=CNC4=CC=CC2=C34)CN5CC(=O)NC5=O
InChI
1S/C19H22N4O2/c1-22-8-11(9-23-10-17(24)21-19(23)25)5-14-13-3-2-4-15-18(13)12(7-20-15)6-16(14)22/h2-4,7,11,14,16,20H,5-6,8-10H2,1H3,(H,21,24,25)/t11-,14-,16-/m1/s1
InChIKey
VXIHQTMCLKWCBN-DJSGYFEHSA-N
CAS Number
CAS 95688-34-9
PubChem Compound ID
125720
PubChem Substance ID
10241414, 15324114, 29305456, 50481416, 103175828, 104361991, 135081012, 224885329, 234888625
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Antagonist [526792], [533340]
Alpha-1D adrenergic receptor Target Info Modulator [533340]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
cGMP-PKG signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Other
References
Ref 533340Mechanism of the antihypertensive effect of FCE 22716, a new ergoline derivative, in the spontaneously hypertensive rat. Pharmacology. 1989;38(2):78-92.
Ref 526792Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598). J Pharmacol Exp Ther. 1992 Jan;260(1):146-59.
Ref 533340Mechanism of the antihypertensive effect of FCE 22716, a new ergoline derivative, in the spontaneously hypertensive rat. Pharmacology. 1989;38(2):78-92.

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