Drug Information

Drug General Information
Drug ID
D09BHF
Former ID
DIB014321
Drug Name
WF-2421
Synonyms
FR-900280
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Terminated [529812]
Company
Fujisawa Pharmaceutical Co Ltd
Formula
C19H20N2O8
Canonical SMILES
c1(c2cc(ccc2O)C(O)CNC=O)cc(C(C(C(=O)O)NC=O)O)ccc1O
CAS Number
CAS 128429-19-6
PubChem Compound ID
195567
Target and Pathway
Target(s) Aldose reductase Target Info Modulator [529812]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 529812WF-2421, a new aldose reductase inhibitor produced from a fungus, Humicola grisea. J Antibiot (Tokyo). 1991 Feb;44(2):130-5.
Ref 529812WF-2421, a new aldose reductase inhibitor produced from a fungus, Humicola grisea. J Antibiot (Tokyo). 1991 Feb;44(2):130-5.

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