Drug Information

Drug General Information
Drug ID
D07RUV
Former ID
DIB000959
Drug Name
Terflavoxate
Synonyms
ND-907; Rec-15-2053
Drug Type
Small molecular drug
Indication Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32] Discontinued in Phase 2 [545426]
Company
Recordati SpA
Formula
C26H29NO4
Canonical SMILES
c12oc(c(c(=O)c2cccc1C(=O)OC(CN1CCCCC1)(C)C)C)c1ccccc1.C<br />l
PubChem Compound ID
135750
Target and Pathway
Target(s) Muscarinic receptor Target Info Modulator [534003]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 545426Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003221)
Ref 534003Effects of terflavoxate on stimulated contractions of urinary bladder in vitro. Arzneimittelforschung. 1993 Feb;43(2):122-8.

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