TTD | Drug: D0X1YF

Drug General Information
Drug ID	D0X1YF
Former ID	DIB010794
Drug Name	T-1095
Synonyms	RWJ-394718; T-0687; T-1095A; SGLT-2 inhibitors (diabetes), Tanabe/Johnson & Johnson
Drug Type	Small molecular drug
Indication	Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1]		Discontinued in Phase 2	[546954]
Company	Tanabe Seiyaku Co Ltd
Formula	C26H28O11
Canonical SMILES	[C@@H]1([C@@H]([C@H]([C@@H]([C@H](O1)COC(=O)OC)O)O)O)Oc<br />1c(c(cc(c1)C)O)C(=O)CCc1cc2c(occ2)cc1
PubChem Compound ID	6918410
Target and Pathway
Target(s)	Sodium/glucose cotransporter 1	Target Info	Modulator	[525583]
KEGG Pathway	Carbohydrate digestion and absorption
	Bile secretion
	Mineral absorption
PathWhiz Pathway	Lactose Degradation
PathWhiz Pathway	Trehalose Degradation
Reactome	Hexose transport
	Na+-dependent glucose transporters
	Inositol transporters
WikiPathways	NRF2 pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Metabolism of carbohydrates
References
Ref 546954	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011538)
Ref 525583	T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes. Diabetes. 1999 Sep;48(9):1794-800.

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Drug Information