Drug Information

Drug General Information
Drug ID
D06ZKG
Former ID
DIB010999
Drug Name
SC-56525
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Terminated [545665]
Company
GD Searle & Co
Canonical SMILES
S(=O)(=O)(N1CCN(CC1)C)C[C@H](C(=O)N[C@H](C(=O)N[C@H]([C<br />@H]([C@H](CC(C)C)O)O)CC1CCCCC1)CC#C)Cc1ccccc1
CAS Number
CAS 159005-44-4
Target and Pathway
Target(s) Renin, renal Target Info Inhibitor [533654]
KEGG Pathway Renin-angiotensin system
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 545665Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004067)
Ref 533654Effects of SC-56525, a potent, orally active renin inhibitor, in salt-depleted and renal hypertensive dogs. Hypertension. 1995 Jul;26(1):95-100.

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