Drug Information

Drug General Information
Drug ID
D00EZE
Former ID
DIB004442
Drug Name
Panamesine
Synonyms
EMD-57445; EMD-59983
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Discontinued in Phase 2 [544890]
Company
Merck KGaA
Formula
C23H26N2O6
Canonical SMILES
C1(=O)N(C[C@@H](O1)CN1CCC(c2cc3c(OCO3)cc2)(CC1)O)c1ccc(<br />cc1)OC
CAS Number
CAS 139225-22-2
PubChem Compound ID
3047810
Target and Pathway
Target(s) Sigma(1)-type opioid receptor Target Info Binder [525495], [526642], [532713]
WikiPathways miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 544890Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001428)
Ref 525495Efficacy and safety of the sigma receptor ligand EMD 57445 (panamesine) in patients with schizophrenia: an open clinical trial. Pharmacopsychiatry. 1999 Mar;32(2):68-72.
Ref 526642Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6.
Ref 532713Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.