Drug Information

Drug General Information
Drug ID
D03JRJ
Former ID
DIB011983
Drug Name
NTE-122
Synonyms
ACAT inhibitor, Nissin Food
Indication Atherosclerosis [ICD9: 414.0, 440; ICD10:I70] Terminated [546451]
Company
Nissin Foods Holdings Co Ltd
Canonical SMILES
C(=O)(N(C[C@H]1CC[C@H](CN(C(=O)Nc2ccc(N(C)C)cc2)C2CCCCC<br />2)CC1)C1CCCCC1)Nc1ccc(N(C)C)cc1
CAS Number
CAS 166967-85-7
Target and Pathway
Target(s) Liver carboxylesterase Target Info Inhibitor [534779]
KEGG Pathway Drug metabolism - other enzymes
Metabolic pathways
Pathway Interaction Database E2F transcription factor network
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Heroin metabolism
Irinotecan Pathway
Fluoropyrimidine Activity
Phase I biotransformations, non P450
References
Ref 546451Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008195)
Ref 534779Cholesterol-lowering effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on cholesterol diet-fed rats and rabbits. Jpn J Pharmacol. 1998 Nov;78(3):355-64.

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