Drug Information

Drug General Information
Drug ID
D0T4IQ
Former ID
DIB003832
Drug Name
MEN-11149
Indication Asthma [ICD10:J45] Terminated [546726]
Company
The Menarini Group
Canonical SMILES
c1(C(=O)N[C@@H]2[C@H](C(=O)N[C@H](N(C(=O)Cc3ccc(cc3)C)C<br />)Cc3cc4c(cc3)cccc4)CCCC2)c[nH]c2c1cccc2
CAS Number
CAS 206052-25-7
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [534597]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 546726Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009948)
Ref 534597Pharmacology of the peptidomimetic, MEN 11149, a new potent, selective and orally effective tachykinin NK1 receptor antagonist. Eur J Pharmacol. 1998 Jan 12;341(2-3):201-9.

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